Antibiotics and the Mitochondria

Inhibition of mitochondrial functions by the antibiotics, bikaverin and duclauxine.

Four cytotoxic antibiotics, bikaverin, duclauxine, PSX-1 and vermiculine, were examined with respect to their interference with glycolysis and respiration and their possible ionophoric or cytolytic activity. Duclauxine was found to be an inhibitor of respiration and bikaverin an uncoupler of oxidative phosphorylation of tumor cells and of isolated rat liver mitochondria. Bikaverin was also foun...

Structure of leucinostatin B, an uncoupler on mitochondria.

A Comparison of Toxicity Mechanisms of Cigarette Smoke on Isolated Mitochondria Obtained from Rat Liver and Skin

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria

The TiO2, which is a main material in the field of photocatalytic reactions, includes rutile and anatase phase. Titanium dioxide has possessed notice due to its promising applications in the environmental photocatalytic degradation of pollutants of organic compound in waste water and utilization of solar energy. The nanosized manganese titanate (pyrophanite) MnTiO3 was collected by oxidation of...

MODULATION OF MITOCHONDRIAL UPTAKE OF A DENOSINE BY NITROBENZYLTHIOINOSINE

In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...

In vitro effect of rifampicin and its derivatives on energy transfer reactions in mitochondria.

In order to clarify the biological effects of rifampicin and its derivatives on liver cells, the actions of these antibiotics on the energy transfer reactions were observed in rat liver mitochondria. Rifampicin, 25-desacetyl rifampicin and rifampicin quinone at concentrations of 2.8x10-5-2.7x10-4M had little effect on the respiration and several energy transfer reactions in rat liver mitochondr...